Effect of early post-extubation high-flow nasal cannula versus conventional low-flow oxygen therapy on reintubation in postoperative patients from prolonged general anesthesia at surgical ICU: A randomized clinical trial (Protocol)

Background: The main concerns following general anesthesia, especially if it lasts longer than 4 hours, are postoperative pulmonary complications, including hypoxemia, lung atelectasis, and acute respiratory failure requiring reintubation. To avoid these extubation with support is crucial. high-flow nasal cannula (HFNC) increases end-expiratory volume reduces the work of breathing to improve oxygenation by delivering a flow-dependent positive airway pressure. advantages using HFNC prevent reintubation have been demonstrated in patients undergoing cardiothoracic surgery. Our target population's information still deficient, our trial set up uncover this proof. Objectives: evaluate effect versus low-flow on rate clinical outcomes early post-extubation adult who has prolonged anesthesia for non-cardiothoracic non-neuro surgery that requires surgical ICU admission. Methods: In study, 260 an intermediate high risk complications non-neurosurgery required hours were randomly assigned receive either or after extubation. primary outcome indicator within 72 tracheal Postoperative length stay hospital, mortality considered secondary measures. Conclusions: This study investigator-initiated randomized controlled powered test hypothesis application probably SICUs durations anesthesia.